Liposome Entrapment of Bacteriophages Improves Wound Healing in a Diabetic Mouse MRSA Infection

Diabetic populations are more prone to developing wound infections. Infection with drug resistant organisms further worsen the situation, driving searches for alternative treatment approaches such as phage therapy.

In the present work we address this issue by employing liposomes as delivery vehicles. A liposome entrapped phage cocktail was evaluated for its ability to resolve a Staphylococcus aureus-induced diabetic excision wound infection.

Entrapment of phage cocktails within liposomes thus could represent an attractive approach for treatment of bacterial infections, not responding to antibiotics as increased phage persistence in vitro and in vivo at the wound site was observed.