عنوان ژورنال کلاب :

Extracellular Vesicles as a Neprilysin Delivery System Memory Improvement in Alzheimer’s Disease

Extracellular Vesicles as a Neprilysin Delivery System Memory Improvement in Alzheimer's Disease ارائه دهنده : دکتر مهرناز ایزدپناه

Alzheimer’s disease (AD) is a neurodegenerative brain disorder which has no effective treatment yet due to the blood barrier in the brain that limits the drugs with the potential of disease improvement. Extracellular vesicles (EVs) are biocompatible nanoparticles with a lipid membrane. Neprilysin (NEP) is an active enzyme in the clearance of abnormal aggregated beta-amyloid sheets in the brain.

In the present study, we used EVs to carry NEP for memory improvement in Alzheimer’s disease.

Our findings showed EV-loaded NEP caused a decrease in IL-1beta and also BAX but an increase in BCL2 expression level in the rat brain. These findings suggest that EV-loaded NEP can be considered as a potential drug delivery system for the improvement of AD.

یک شنبه 11 اسفند 

ساعت 15 الی 16

شرکت در ژورنال کلاب های شرکت لیوژن فارمد برای عموم علاقه مندان آزاد است.