کشف آنتی بیوتیک جدید که عکس پنی سیلین عمل می کند. کربومایسین سعید کارگر لیوژن فارمد

کربومایسین ، آنتی بیوتیک جدیدی با عملکرد عکس پنی سیلین

کربومایسین تازه کشف شده با روشی منجر به کشته شدن باکتری ها می شود که تاکنون دیده نشده بود. این آنتی بیوتیک در خانواده گلیکوپپتیدها قرار دارد که به وسیله باکتری های موجود در خاک تولید می شود. محققین نشان دادند که این آنتی بیوتیک می تواند موش آلوده شده Staphylococcus aureus که مقاومت دارویی و منشا بسیاری عفونت های مهم است. این نتایج در ژورنال نیچر به چاپ رسیده است.

باکتری ها در اطراف خود دیواره ای دارند که به آن ها شکل می دهد و موجب قدرت آن ها می شود. آنتی بیوتیک پنی سیلین با جلوگیری کردن از ساخته شدن دیواره سلولی جدید در باکتری، موجب کشته شدن آن ها می شود، اما این آنتی بیوتیک دقیقا عکس آنتی بیوتیک پنی سیلین عمل می کند و از تجزیه دیواره سلولی جلوگیری می کند.

برای اینکه یک سلول رشد و تکثیر بکند، نیاز است که دیواره آن بشکند و دیواره جدید به آن قسمت اضافه بشود. اگر از شکسته شدن دیواره سلولی جلوگیری بشود، دیواره مثل یک زندان می شود که از رشد و تکثیر باکتری جلوگیری می کند.

کشف آنتی بیوتیک جدید که عکس پنی سیلین عمل می کند. کربومایسین سعید کارگر لیوژن فارمد
کشف آنتی بیوتیک جدید که عکس پنی سیلین عمل می کند

Antibiotics discovered that kill bacteria in a new way

Date:February 12, 2020

Source:McMaster University

Summary:A new group of antibiotics with a unique approach to attacking bacteria has been discovered, making it a promising clinical candidate in the fight against antimicrobial resistance.Y


A new group of antibiotics with a unique approach to attacking bacteria has been discovered, making it a promising clinical candidate in the fight against antimicrobial resistance.

The newly-found corbomycin and the lesser-known complestatin have a never-before-seen way to kill bacteria, which is achieved by blocking the function of the bacterial cell wall. The discovery comes from a family of antibiotics called glycopeptides that are produced by soil bacteria.

The researchers also demonstrated in mice that these new antibiotics can block infections caused by the drug resistant Staphylococcus aureus which is a group of bacteria that can cause many serious infections.

The findings were published in Nature today.

“Bacteria have a wall around the outside of their cells that gives them shape and is a source of strength,” said study first author Beth Culp, a PhD candidate in biochemistry and biomedical sciences at McMaster.

“Antibiotics like penicillin kill bacteria by preventing building of the wall, but the antibiotics that we found actually work by doing the opposite — they prevent the wall from being broken down. This is critical for cell to divide.

“In order for a cell to grow, it has to divide and expand. If you completely block the breakdown of the wall, it is like it is trapped in a prison, and can’t expand or grow.”

Looking at the family tree of known members of the glycopeptides, researchers studied the genes of those lacking known resistance mechanisms, with the idea they might be an antibiotic demonstrating a different way to attack bacteria.

“We hypothesized that if the genes that made these antibiotics were different, maybe the way they killed the bacteria was also different,” said Culp.

The group confirmed that the bacterial wall was the site of action of these new antibiotics using cell imaging techniques in collaboration with Yves Brun and his team from the Université de Montréal.

Culp said: “This approach can be applied to other antibiotics and help us discover new ones with different mechanisms of action. We found one completely new antibiotic in this study, but since then, we’ve found a few others in the same family that have this same new mechanism.”

The team is led by professor Gerry Wright of the David Braley Centre for Antibiotic Discovery within the Michael G. DeGroote Institute for Infectious Disease Research at McMaster.

The research was funded by the Canadian Institutes of Health Research and the Ontario Research Fund.


Story Source:

Materials provided by McMaster University. Original written by Tina Depko. Note: Content may be edited for style and length.


Journal Reference:

  1. Elizabeth J. Culp, Nicholas Waglechner, Wenliang Wang, Aline A. Fiebig-Comyn, Yen-Pang Hsu, Kalinka Koteva, David Sychantha, Brian K. Coombes, Michael S. Van Nieuwenhze, Yves V. Brun, Gerard D. Wright. Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodellingNature, ۲۰۲۰; DOI: ۱۰.۱۰۳۸/s41586-020-1990-9
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