Livogen Pharmed Copmany

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The elimination of host cell impurities is a significant step in the purification of biopharmaceutical products. Consistent with the Food and Drug Administration (FDA) guidelines, the DNA content in the final product should be as low as possible as established by the most precise method, with the maximum adequate amount of residual host DNA being 100 pg/therapeutic dose.This CHO DNA kit is a quantitative PCR (qPCR)-based kit that allows you to identify sub-picogram quantities of residual DNA from the Chinese hamster ovary (CHO) cell line in less than 24h. The system overcomes the restraints of customary methods by TaqMan®-based quantitation of residual DNA. The kit is able to isolate <1pg/mL levels of residual DNA. It includes ready-to-use Probe/ROX qPCR Master Mix (2X) set up for quantitative real-time PCR. The master mix includes Hot Start Taq DNA Polymerase and dNTPs in an optimized PCR buffer.

Intended Use

  • Available for research use only (RUO). Not for use in diagnostic procedures.